Products for Research Use Only
RegisterLogin

Ponsegromab

CAT: 0804-HY-P99241-01Size: 1 mgDry Ice: YesHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-P99241-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Ponsegromab (PF 06946860) is a potent and selective humanized anti-GDF15 monoclonal antibody with anti-cachexia activity. Ponsegromab binds to GDF15 and prevents the binding of GDF15 to GFRAL, thereby blocking GDF15/GFRAL-mediated signaling. Ponsegromab can be used in the research of cancers[1][2].
CAS Number
2368950-15-4
Product Name Alternative
PF 06946860
UNSPSC
12352203
Target
TGF-beta/Smad
Type
Inhibitory Antibodies
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ponsegromab.html
Purity
99.41
Solubility
10 mM in DMSO
Smiles
[Ponsegromab]
Molecular Weight
(145.5 kDa)
References & Citations
[1]E.J. Roeland, et al. 1696TiP Phase Ib study to assess the effect of PF-06946860 on appetite following subcutaneous administration in patients with anorexia and advanced cancer. VOLUME 32, SUPPLEMENT 5, S1185, SEPTEMBER 01, 2021. Annals of oncology. |[2]Groarke JD, et al. Ponsegromab for the Treatment of Cancer Cachexia. N Engl J Med. 2024 Dec 19;391 (24) :2291-2303.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 3

Alternative Products

CatalogName
MBS5818700Ponsegromab
GTR18338011-01Ponsegromab Antibody
E55B0807Ponsegromab (Reference antibody)
WA3376Research Grade Ponsegromab
592122-01GDF15, Ponsegromab Biosimilar
A137793Ponsegromab Biosimilar (Monoclonal, IgG1)
047652GDF15/MIC1 (ponsegromab) discontinued
ICH5182-100mgPonsegromab Biosimilar - Research Grade
GTR18697347-01Ponsegromab Human Monoclonal Antibody
GTR18780288-01(Ponsegromab) Biosimilar Reference Antibody

Popular Products