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Forkhead box protein P3

CAT: 0579-X2349BSize: 50 µgDry Ice: NoHazardous: No
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CAT#:0579-X2349BSize:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Probable transcription factor. Plays a critical role in the control of immune response. Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX); also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.
Synonyms
FOXP3
UniProt
Q9BZS1 (Human)
Host
Rabbit
Species Reactivity
Human
Conjugation
Unconjugated
Type
Blocking Peptide
Applications
WB
Assay Principle
For use with FOXP3 polyclonal antibodies (Cat. No. X2347P , X2348P).
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
Provided as solution in phosphate buffered saline
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
References & Citations
1. Bennett, C.L., et al. 'The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.; Nat. Genet. 27:20-21(2001). 2. Wildin, R.S., et al. 'X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the Human equivalent of mouse scurfy.; Nat. Genet. 27:18-20(2001). 3. Brunkow, M.E., et al. 'Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.; Nat. Genet. 27:68-73(2001).
Shipping Conditions
Ambient Temperature, freeze upon arrival
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
WB

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