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Piceatannol

CAT: 0804-HY-13518-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13518-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Piceatannol is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI) [1]. Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties[2]. Piceatannol induces apoptosis in DLBCL cell lines[3]. Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells[4].
CAS Number
10083-24-6
Product Name Alternative
Astringenin; trans-Piceatannol
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Endogenous Metabolite; Syk
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Piceatannol.html
Purity
98.97
Solubility
DMSO : 97.47 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
OC1=CC=C(/C=C/C2=CC(O)=CC(O)=C2)C=C1O
Molecular Formula
C14H12O4
Molecular Weight
244.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Lu-Yuan Peng, et al. Protective Effect of Piceatannol Against Acute Lung Injury Through Protecting the Integrity of Air-Blood Barrier and Modulating the TLR4/NF-κB Signaling Pathway Activation. Front Pharmacol. 2020 Jan 22;10:1613.|[2]Jonathan Kershaw, et al. The Therapeutic Potential of Piceatannol, a Natural Stilbene, in Metabolic Diseases: A Review. J Med Food. 2017 May;20 (5) :427-438.|[3]Andrea Rinaldi, et al. In vitro efficacy of tyrosine kinase inhibitors: SYK and BCR-ABL inhibitors in lymphomas.Hematol Oncol. 2011 Sep;29 (3) :164-6.|[4]Kamila Siedlecka-Kroplewska, et al. Induction of autophagy, apoptosis and aquisition of resistance in response to piceatannol toxicity in MOLT-4 human leukemia cells. Toxicol In Vitro. 2019 Sep;59:12-25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 1

Alternative Products

CatalogName
1554/10Piceatannol

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