Regorafenib N-oxide and N-desmethyl (M5)

• UNSPSC Description:

  Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4[1].

• Target Antigen:

  c-Kit; Drug Metabolite; Raf; VEGFR

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway;Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/regorafenib-n-oxide-and-n-desmethyl-m5.html

• Smiles:

  O=C(C1=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C(F)=C2)=CC=[N+]1[O-])N

• Molecular Weight:

  484.79

• References & Citations:

  [1]Ying-Hui Li, et al. Functional characterization of 27 CYP3A4 protein variants to metabolize regorafenib in vitro. Basic Clin Pharmacol Toxicol. 2019 Oct;125(4):337-344.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  835621-12-0