Regorafenib N-oxide and N-desmethyl (M5)

Regorafenib N-oxide and N-desmethyl (M5)

• CAS Number: 835621-12-0
• UNSPSC Description: Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4[1].
• Target Antigen: c-Kit; Drug Metabolite; Raf; VEGFR
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway;Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/regorafenib-n-oxide-and-n-desmethyl-m5.html
• Smiles: O=C(C1=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C(F)=C2)=CC=[N+]1[O-])N
• Molecular Weight: 484.79
• References & Citations: [1]Ying-Hui Li, et al. Functional characterization of 27 CYP3A4 protein variants to metabolize regorafenib in vitro. Basic Clin Pharmacol Toxicol. 2019 Oct;125(4):337-344.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported