TUG-469

TUG-469

• CAS Number: 1236109-67-3
• UNSPSC Description: TUG-469 is a selective free fatty acid receptor 1 (FFA1/GPR40) agonist with an EC50 value of 19 nM. TUG-469 is >200-fold selective for FFA1 over FFA4. TUG-469 significantly improves glucose tolerance in pre-diabetic mice. TUG-469 can be used for the research of diabetes[1][2].
• Target Antigen: Free Fatty Acid Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/tug-469.html
• Purity: 99.90
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(CCC1=CC=C(C=C1)NCC2=CC(C3=CC=CC=C3C)=CC=C2)O
• Molecular Weight: 345.43
• References & Citations: [1]Christiansen E, et al. Structure-Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1 (GPR40) Agonist TUG-469. ACS Med Chem Lett. 2010 Jul 2;1(7):345-9.|[2]Urban C, et al. In vitro and mouse in vivo characterization of the potent free fatty acid 1 receptor agonist TUG-469. Naunyn Schmiedebergs Arch Pharmacol. 2013 Dec;386(12):1021-30.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported