SR-3677

• UNSPSC Description:

  SR-3677 is a potent and selective ROCK-II inhibitor with an IC50 of ~3 nM.

• Target Antigen:

  Autophagy; ROCK

• Type:

  Reference compound

• Related Pathways:

  Autophagy;Cell Cycle/DNA Damage;Cytoskeleton;Stem Cell/Wnt;TGF-beta/Smad

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/SR-3677.html

• Smiles:

  CN(C)CCOC1=C(NC(C2OC(C=CC=C3)=C3OC2)=O)C=CC(C4=CNN=C4)=C1

• Molecular Weight:

  408.45

• References & Citations:

  [1]Feng Y, et al. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem. 2008 Nov 13;51(21):6642-5.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  1072959-67-1