Thalidomide-O-amido-C6-NH2 (hydrochloride)

Thalidomide-O-amido-C6-NH2 (hydrochloride)

• CAS Number: 2376990-31-5
• UNSPSC Description: Thalidomide-O-amido-C6-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].
• Target Antigen: Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/thalidomide-o-amido-c6-nh2-hydrochloride.html
• Purity: 99.32
• Solubility: 10 mM in DMSO
• Smiles: O=C(NCCCCCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.[H]Cl
• Molecular Weight: 466.92
• References & Citations: [1]Bradner J, et al. Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses. WO 2017024318 A1
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported