Mutant IDH1-IN-1

Mutant IDH1-IN-1

• CAS Number: 1355326-21-4
• UNSPSC Description: Mutant IDH1-IN-1 is a mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively.
• Target Antigen: Isocitrate Dehydrogenase (IDH)
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/Mutant-IDH1-IN-1.html
• Purity: 99.43
• Solubility: DMSO : ≥ 45 mg/mL
• Smiles: O=C(C(C1=C(C)C=CC=C1)N(C(CN2C=NC3=C2C=CC=C3)=O)C4=CC(F)=CC=C4)NC5CCCCC5
• Molecular Weight: 498.59
• References & Citations: [1]Deng G, et al. Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule. J Biol Chem. 2015 Jan 9;290(2):762-74.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported