Lenoremycin

CAT: 0804-HY-129694Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-129694Size:1 Each

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Description

Lenoremycin (Ro 21-6150) is a microbial metabolite. Lenoremycin decreases β-catenin and cyclin D1 proteins levels. Lenoremycin decreases cancer stem cells (CSCs) populations via inducing reactive oxygen species production[1].

CAS Number

51257-84-2

Product Name Alternative

Ro 21-6150; Antibiotic A-130-A

UNSPSC

12352005

Target

CDK; Reactive Oxygen Species (ROS) ; β-catenin

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lenoremycin.html

Smiles

C[C@H]1[C@]2(O[C@](C[C@H]1O[C@@H]3O[C@@H]([C@H](CC3)OC)C)([H])[C@@H](C)/C=C(C)/C([C@H](C)C[C@H](C)C(O)=O)=O)O[C@@](CC2)([C@]4([H])O[C@@]5([C@@H](CC4)C)O[C@]([C@@]6([H])O[C@](O)([C@@H](C[C@@H]6C)C)CO)([H])C[C@@H]5C)C

Molecular Formula

C47H78O13

Molecular Weight

851.11

References & Citations

[1]Ikeda H, et al. Identification of the polyether ionophore lenoremycin through a new screening strategy for targeting cancer stem cells. J Antibiot (Tokyo) . 2022 Dec;75 (12) :671-678.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

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