SIRT2-IN-11
CAT:
804-HY-148408-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
SIRT2-IN-11
- CAS Number: 1005095-06-6
- UNSPSC Description: SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor with an IC50 value of 18.5 μM. SIRT2-IN-11 p53-dependently induces apoptosis, activates expression of CDKN1A, PUMA and NOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers[1].
- Target Antigen: Sirtuin
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Epigenetics
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/sirt2-in-11.html
- Solubility: DMSO : 250 mg/mL (ultrasonic)
- Smiles: O=C(C1=CC=C2NC(C3C(C4CCC3C4)C2=C1)C5=CC=CC=C5)N
- Molecular Weight: 318.41
- References & Citations: [1]Hoffmann G, et al. A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer. J Biol Chem. 2014 Feb 21;289(8):5208-16.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported