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PB200

CAT: 0804-HY-168508Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168508Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PB200 is an HDAC6 inhibitor with an IC50 value of 1.97 nM. PB200 demonstrates significant antidepressant effects by restoring abnormal HDAC6 expression levels and alleviating neuroinflammation[1].
UNSPSC
12352211
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pb200.html
Smiles
CC1=CC=C2CCCN(C2=N1)CC3=C(C=C(C=C3)C(NO)=O)F
Molecular Formula
C17H18FN3O2
Molecular Weight
315.34
References & Citations
[1]Zhong X, et al. PET Imaging Assist Investigation of HDAC6 Expression Change in MDD and Evaluating Antidepressant Efficacy of a Newly Developed HDAC6 Inhibitor[J]. European Journal of Medicinal Chemistry, 2024: 116908.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC6

Alternative Products

CatalogName
T201308-01PB200

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