1-Stearoyl-2-15(S)-Hpete-Sn-Glycero-3-Pe

1-Stearoyl-2-15(S)-Hpete-Sn-Glycero-3-Pe

• Product Name Alternative: SC-39026; Declaben
• CAS Number: 154436-49-4
• UNSPSC Description: 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe is a phospholipid that contains stearic acid (HY-B2219) at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-Pe (SAPE) by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3.
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/1-stearoyl-2-15-s-hpete-sn-glycero-3-pe.html
• Smiles: O=C(CCC/C=C\C/C=C\C/C=C\C=C\[C@@H](OO)CCCCC)O[C@H](COC(CCCCCCCCCCCCCCCCC)=O)COP(OCCN)(O)=O
• Molecular Weight: 800.05
• References & Citations: [1]Kagan, et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat. Chem. Biol. 13(1), 81-90 (2017).
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported