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COH29

CAT: 0804-HY-19931-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19931-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
COH29 (RNR Inhibitor COH29) is a potent ribonucleotide reductase (RNR) inhibitor with anticancer activity. COH29 inhibits α and β subunit of RNR with IC50s of 16 μM.
CAS Number
1190932-38-7
Product Name Alternative
RNR Inhibitor COH29
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/COH29.html
Purity
98.76
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NC1=NC(C2=CC=C(O)C(O)=C2)=C(C3=CC=CC=C3)S1)C4=CC=C(O)C(O)=C4
Molecular Formula
C22H16N2O5S
Molecular Weight
420.44
Precautions
H315, H319, H335
References & Citations
[1]Zhou B, et al. A small-molecule blocking ribonucleotide reductase holoenzyme formation inhibits cancer cell growth and overcomes drug resistance.Cancer Res. 2013 Nov 1;73 (21) :6484-93.|[2]Chen MC, et al. The Novel Ribonucleotide Reductase Inhibitor COH29 Inhibits DNA Repair In Vitro. Mol Pharmacol. 2015 Jun;87 (6) :996-1005.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

Alternative Products

CatalogName
A17168-10COH29 10mg
MBS3842143-01COH29
A17168-50COH29 50mg
A17168-25COH29 25mg
A17168-5COH29 5mg
A17168-1COH29 1mg
A17168-100COH29 100mg
A17168-2COH29 2mg
A17168-10mM-DCOH29 10mM * 1mL in DMSO

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