Anti-Hu CD49e Purified

Anti-Hu CD49e Purified

• Background: CD49e (VLA5 alpha) is a type I transmembrane glycoprotein of the integrin alpha subclass (intergrin 5 alpha), expressed on thymocytes, early and activated B cells, monocytes, NK cells, dendritic cells, osteoblast and endothelial cells. It binds to RGD sequence in fibronectin and to neural adhesion molecule L1. CD49e interactions are important for maintaining the integrity of the endothelial monolayer, as well as it is involved in monocyte migration, T cell costimulation, regulation of cell survival, and other.
• Specifications: The mouse monoclonal antibody SAM1 recognizes an extracellular epitope of CD49e (integrin 5 alpha), a transmembrane glycoprotein expressed on thymocytes, early and activated B cells, monocytes, NK cells, dendritic cells, osteoblast and endothelial cells.
• CAS Number: 9007-83-4
• Certification: RUO
• Host: Mouse
• Species Reactivity: Non-human primates, Human
• Immunogen: U937 cells
• Target Antigen: CD49e
• Isotype: IgG2b
• Clone: SAM1
• Applications: Flow cytometry: Recommended dilution: 1-4 μg/mL.
• Validated Applications: FC, IP, IHC-F
• Concentration: 1 mg/mL
• Format: Purified
• Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• References & Citations: *Blase L, Merling A, Engelmann S, Möller P, Schwartz-Albiez R: Characterization of cell surface-expressed proteochondroitin sulfate of pre-B Nalm-6 cells and its possible role in laminin adhesion. Leukemia 1996 Jun10(6):1000-11., URL: https://pubmed.ncbi.nlm.nih.gov/8667635/,*Tachimoto H, Hudson SA, Bochner BS: Acquisition and alteration of adhesion molecules during cultured human mast cell differentiation. J Allergy Clin Immunol. 2001 Feb107(2):302-9, URL: https://pubmed.ncbi.nlm.nih.gov/11174197/,*Malara A, Gruppi C, Rebuzzini P, Visai L, Perotti C, Moratti R, Balduini C, Tira ME, Balduini A: Megakaryocyte-matrix interaction within bone marrow: new roles for fibronectin and factor XIII-A. Blood 2011 Feb 24117(8):2476-83. , URL: https://pubmed.ncbi.nlm.nih.gov/21131589/,*Lessey BA, Castelbaum AJ, Buck CA, Lei Y, Yowell CW, Sun J: Further characterization of endometrial integrins during the menstrual cycle and in pregnancy. Fertil Steril. 1994 Sep62(3):497-506., URL: https://pubmed.ncbi.nlm.nih.gov/8062944/,
• Storage Conditions: Store at 2-8°C. Do not freeze.