Anti-Rb Protein Antibody

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Alternative Products

Cat	Name
3104	Anti-Rb Protein Antibody
3106	Anti-Rb Protein Antibody
3104	Anti-Rb Protein Antibody
3105	Anti-Rb Protein Antibody
3106	Anti-Rb Protein Antibody
3101	Anti-Rb Protein Antibody
3102	Anti-Rb Protein Antibody
3103	Anti-Rb Protein Antibody
3107	Anti-Rb Protein Antibody
3101	Anti-Rb Protein Antibody

CAT:

14-3101-1

Size:

100 µg

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Anti-Rb Protein Antibody

Description: Mouse Monoclonal Antibody specific to Rb Protein
Alternative Name: p105-Rb, p110-RB1, pRb, Rb, pp110
Gene Name: RB1
Gene ID: 5925
NCBI Gene ID: RB1
UniProt: P06400
Accession Number: NP_000312
Cellular Locus: Nucleus
Host: Mouse
Reactivity: Human
Immunogen: Recombinant retinoblastoma
Target Antigen: Retinoblastoma-associated protein
Target: Rb Protein
Clonality: Monoclonal
Isotype: IgG1
Type: Antibody
Applications: WB, IP, IHC, ELISA
Field of Research: Cancer Research
Purification Method: Purified by Protein G affinity chromatography
Concentration: Lot Specific
Dilution: Dilute in PBS or medium which is identical to that used in the assay system.
Format: Purified
Form: Liquid
Buffer: Phosphate Buffered Saline
Function: Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {UniProtKB:P13405, UniProtKB:P33568, PubMed:10499802, PubMed:15084261}.; (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {PubMed:1316611, PubMed:17974914, PubMed:18701596, PubMed:2839300, PubMed:8892909}.
Storage Conditions: These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
Specificity: Recombinant rat PSD95
Formulation: PBS, pH 7.4
Buffer pH: pH 7.4

Complementary Product Range

Our range of products, including Anti-Rb Protein Antibody, falls within the same field of application and can be used across various research projects. These products are carefully selected for their high performance and reliability, supporting the diverse needs of modern laboratories. Whether for ongoing studies or future experiments, they are designed to help researchers achieve their scientific goals. Here are some related products that may be of interest for similar or future applications:

Each item in our collection, is tested for precision and quality, ensuring dependable solutions for your research. As we continue to incorporate the latest advancements, Gentaur ensures that our product range remains relevant and versatile, providing you with the tools needed for both current and future projects.

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Cat	Name
3103-1	Anti-Rb Protein Antibody
3106-1	Anti-Rb Protein Antibody
3107-1	Anti-Rb Protein Antibody
3101-1	Anti-Rb Protein Antibody
3102-1	Anti-Rb Protein Antibody
3104-1	Anti-Rb Protein Antibody
3105-1	Anti-Rb Protein Antibody
BA1372VSER-1	Chlamydia trachomatis EB + RB Antigen
BA1371VSER-1	Chlamydia pneumoniae EB and RB Antigen
BA1373VSER-1	Chlamydia abortus EB & RB (elementary and reticular bodies) Antigen