Glutathione Peroxidase 2 Recombinant Rabbit Monoclonal Antibody [JE40-73]

• Description:

  Glutathione peroxidase 2 is an enzyme that in humans is encoded by the GPX2 gene. This gene is a member of the glutathione peroxidase family encoding a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. Studies in knockout mice indicate that mRNA expression levels respond to luminal microflora, suggesting a role of the ileal glutathione peroxidases in preventing inflammation in the GI tract. The antioxidant enzyme glutathione peroxidase 2 (Gpx2) is one out of eight known glutathione peroxidases (Gpx1-8) in humans. Mammalian Gpx1, GPx2 (this protein), Gpx3, and Gpx4 have been shown to be selenium-containing enzymes, whereas Gpx6 is a selenoprotein in humans with cysteine-containing homologues in rodents. In selenoproteins, the 21st amino acid selenocysteine is inserted in the nascent polypeptide chain during the process of translational recoding of the UGA stop codon.

• Product Name Alternative:

  Gastrointestinal glutathione peroxidase antibody GI GPx antibody Glutathione peroxidase 2 (gastrointestinal) antibody Glutathione peroxidase 2 antibody Glutathione peroxidase gastrointestinal antibody Glutathione peroxidase related protein 2 antibody Glutathione peroxidase-gastrointestinal antibody Glutathione peroxidase-related protein 2 antibody GPRP antibody GPRP-2 antibody GPx 2 antibody GPx-2 antibody GPx-GI antibody GPX2 antibody GPX2_HUMAN antibody GSHPx 2 antibody GSHPx GI antibody GSHPx-2 antibody GSHPx-GI antibody

• Abbreviation:

  GPX2

• Swiss Prot:

  P18283 Human

• Cellular Locus:

  Cytoplasm, cytosol.

• Host:

  Rabbit

• Species Reactivity:

  Human

• Immunogen:

  Synthetic peptide within C terminal Human Glutathione Peroxidase 2/GPX2.

• Isotype:

  IgG

• Clone:

  JE40-73

• Conjugation:

  Non-conjugated

• Type:

  Recombinant Rabbit monoclonal Antibody

• Applications:

  WB

• Positive Control:

  SW620 cell lysate, LoVo cell lysate, HT-29 cell lysate, AGS cell lysate.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:1,000

• Purity:

  Protein A affinity purified.

• Form:

  Liquid

• Buffer:

  1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 22 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  Yes

• CAS Number:

  9000-83-3