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Slotoxin

CAT: 0804-HY-P3111Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P3111Size:1 Each
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Description
Slotoxin, a peptide from Centruroides noxius Hoffmann scorpion venom, blocks high conductance calcium-activated potassium channel, with Kd of 1.5 nM[1].
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/slotoxin.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N)[C@@H](C)O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H]2CCCCN)=O)=O)CCCNC(N)=N)=O)CC(O)=O)=O)C(C)C)=O)=O)CC3=CC=CC=C3)=O)C)=O)C)=O)CCCCN)=O)CSSC[C@H](NC4=O)C(N[C@H](C(N[C@H](C(O)=O)C(C)C)=O)CC5=CC=C(O)C=C5)=O)=O)CCC1)=O)C)=O)CC6=CNC7=CC=CC=C67)=O)CSSC[C@H](NC8=O)C(N[C@H]4CCCCN)=O)=O)CCC(O)=O)=O)CCCCN)=O)CO)=O)C(C)C)=O)[C@@H](C)O)=O)CSSC[C@H](NC2=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H]8CCCCN)=O)CCCCN)=O)=O)CCSC)=O)=O)CC(O)=O)=O)C(C)C)=O)CC(O)=O)=O)[C@H](CC)C)=O)CC9=CC=CC=C9
Molecular Formula
C177H275N47O50S7
Molecular Weight
4085.82
References & Citations
[1]Garcia-Valdes J, et al. Slotoxin, αKTx1.11, a new scorpion peptide blocker of MaxiK channels that differentiates between α and α+β (β1 or β4) complexes. FEBS Lett. 505 (3) : 369–73.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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