Anti-Laminin(A5)

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Anti-Laminin(A5)

CAT:

37-BNUB0308-100

Size:

100 µL

Price:

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Anti-Laminin(A5)

Description: Laminins are large hetero-trimeric, non-collagenous glycoproteins composed of α, β, and γ chains. This MAb reacts with laminin B2/1 chain of ~210 kDa and does not cross-react with other basement membrane components or fibronectin. Its specificity was established by immunoprecipitation and immunofluorescence of human skeletal muscle and kidney with laminin chain-specific MAbs. Epithelial sheets in vivo are separated from the mesenchymal elements of the stroma by a thin layer of a specialized type of extracellular matrix termed the basement membrane (BM). This structure consists of individual components, some of which are ubiquitous in BMs and some are not. The ubiquitous ones comprise laminin (LN), entactin/nidogen (EN), collagen type IV (CIV), and large heparan sulfate proteoglycan (HSPG), which interact specifically with each other to form a continuous and regular BM. Alterations of BM integrity, from local discontinuities up to complete loss, are described in many types of human and animal epithelial neoplasms. This MAb stains uniformly all human and murine basement membranes.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Synonyms: LAMB2; LAMC1; Laminin B2 chain; Laminin gamma 1; Laminin gamma 1 chain
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: LAMC1
Gene ID: 3915
NCBI Gene ID: 609663
UniProt: P11047, Q5VYE7; Q6NVY8
Cellular Locus: Extracellular matrix
Host: Rat
Species Reactivity: Human, Mouse
Immunogen: Murine EHS laminin preparation
Target Antigen: Laminin
Clonality: Monoclonal
Isotype: IgG2a κ
Clone: A5
Conjugation: Purified, with BSA
Source: Animal
Field of Research: Cancer
Positive Control: Normal colon or carcinomas
Concentration: 0.2 mg/mL
Buffer: PBS, 0.05% BSA, 0.05% azide
Molecular Weight: 210 kDa
Additionnal Information: For coating for ELISA, order Ab without BSA|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Optimal dilution and staining procedure for a specific application should be determined by user|Recommended starting concentrations for titration are 1-2 ug/mL for most applications, or 1 ug/million cells/100 uL for flow cytometry
References & Citations: Ljubimov AV et. al., Int J Cancer, 1992; 50:562-566. | Ljubimov AV et. al. Lab Investigation, 1995; 72:461-473. | Folkvord et. al., J Histochem Cytochem, 1989; 37:105-113
Shipping Conditions: Room temperature
Storage Conditions: 4°C; Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: 2 years

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Cat	Name
BNUB0308-100	Anti-Laminin(A5)
BNUB0308-500	Anti-Laminin(A5)
BNUM0308-50	Anti-Laminin(A5)
BNC740308-100	Anti-Laminin(A5), CF740 conjugate
BNC060308-100	Anti-Laminin(A5), CF405L conjugate
BNC060308-500	Anti-Laminin(A5), CF405L conjugate
BNC400308-100	Anti-Laminin(A5), CF640R conjugate
BNC430308-100	Anti-Laminin(A5), CF543 conjugate
BNC470308-100	Anti-Laminin(A5), CF647 conjugate
BNC470308-500	Anti-Laminin(A5), CF647 conjugate