Anti-Hepatocyte Specific(HepPar1), CF740 conjugate

• Description:

  Hepatocyte Paraffin 1 or HepPar1 localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangiocarcinomas. HCCs occur primarily in the stomach, but they are also found in many other organs. The Hepatocyte Specific Antigen may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of the Hepatocyte Specific Antigen correlates with smaller tumor size and longer patient survival. Occasionally, Hepatocyte Specific Antigen is also found in gastric carcinomas as well as in a few other non-hepatic tumors. The HepPar1 antigen is reported to be carbamoyl phosphate synthetase 1, which is not expressed in immortalized hepatocyte cell lines like HepG2._x000D_ _x000D_ Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors._x000D_ _x000D_

• Synonyms:

  Not Known

• CAS Number:

  9007-83-4

• UNSPSC:

  41116161

• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene ID:

  Not Known

• NCBI Gene ID:

  Not Known

• UniProt:

  Not Known

• Cellular Locus:

  Cytoplasmic

• Host:

  Mouse

• Species Reactivity:

  Dog, Human

• Immunogen:

  Extract of a formalin-fixed, rejected-allograft of a human liver

• Target Antigen:

  Hepatocyte Specific Antigen

• Clonality:

  Monoclonal

• Isotype:

  IgG1 κ

• Clone:

  HepPar1

• Conjugation:

  CF740

• Disease:

  Tumor

• Source:

  Animal

• Applications:

  IHC, FFPE (verified)

• Validated Applications:

  IHC, FFPE

• Field of Research:

  Cancer

• Positive Control:

  Liver or Hepatocellular Carcinoma (HCC)

• Concentration:

  0.1 mg/mL

• Buffer:

  PBS, 0.1% rBSA, 0.05% azide

• Molecular Weight:

  Not Known

• Additionnal Information:

  Does not react with immortalized hepatocyte cell lines|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Immunofluorescence 0.5-1.0 ug/mL

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life:

  2 years