Anti-Interferon alpha-1 (IFNA1)(2-48), CF488A conjugate

• Description:

  This MAb is specific for human interferon alpha 1 and does not cross react with human interferon alpha 2. Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon- Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.
• Synonyms:

  IFN alpha; IFN alpha 1/13; IFN alpha 1b; Interferon alpha 13 (IFNA13); Interferon alpha leukocyte (IFL); Interferon alpha-1/13 (IFN-alpha-1/13); Interferon alpha-D (IFN alphaD); Interferon alpha1 (IFNA1); LeIF D
• CAS Number:

  9007-83-4
• UNSPSC:

  41116161
• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application
• Gene Name:

  IFNA1
• Gene ID:

  3439
• NCBI Gene ID:

  37026 & 533471
• UniProt:

  P01562
• Cellular Locus:

  Secreted (extracellular)
• Host:

  Mouse
• Species Reactivity:

  Human
• Immunogen:

  Purified recombinant human IFN-alpha1
• Target Antigen:

  Interferon Alpha-1
• Clonality:

  Monoclonal
• Isotype:

  IgG1 κ
• Clone:

  17564
• Conjugation:

  CF488A
• Source:

  Animal
• Field of Research:

  Cytokines, Immunology, Inflammation
• Positive Control:

  Stimulated human peripheral blood mononuclear cells
• Concentration:

  0.1 mg/mL
• Buffer:

  PBS, 0.1% BSA, 0.05% azide
• Molecular Weight:

  16-27 kDa
• Additionnal Information:

  For coating for ELISA, order Ab without BSA|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Optimal dilution and staining procedure for a specific application should be determined by user|Recommended starting concentrations for titration are 1-2 ug/mL for most applications, or 1 ug/million cells/100 uL for flow cytometry
• Shipping Conditions:

  Room temperature
• Storage Conditions:

  4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.
• Shelf Life:

  2 years