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FT113

CAT: 0804-HY-111551-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111551-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme. In cell-based assay, FT113 blocks FASN activity in BT474 cells (IC50, 90 nM) . FT113 shows anti-proliferative activity, and exhibits anti-cancer activity both in vitro and in vivo[1].
CAS Number
1630808-89-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Fatty Acid Synthase (FASN)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/FT113.html
Purity
99.39
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C(C1(CC1)O)N2CCN(C(C3=CC=C(C4=NC5=C(C=C(F)C=C5)O4)C=C3)=O)CC2
Molecular Formula
C22H20FN3O4
Molecular Weight
409.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Martin MW, et al. Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN) . Bioorg Med Chem Lett. 2019 Apr 15;29 (8) :1001-1006.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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