Hellebrin

CAT: 0804-HY-129236-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-129236-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Hellebrin is a bufadienolide compound extracted from plants that can inhibit tumor cell growth. Hellebrigenin shows potential in overcoming cancer cells' resistance to apoptosis stimuli and has also demonstrated anti-proliferation effects in multidrug-resistant (MDR) cancer cell models. Hellebrin can act on Na+/K+-ATPase to regulate intracellular signaling pathways[1].

CAS Number

13289-18-4

UNSPSC

12352005

Hazard Statement

H300+H310+H330

Target

Apoptosis; Na+/K+ ATPase

Type

Reference compound

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hellebrin.html

Smiles

O=C1C=CC([C@H]2CC[C@@]3([C@@]4(CC[C@@]5(C[C@H](CC[C@@]5([C@]4(CC[C@]23C)[H])C=O)O[C@]6([C@H](O)[C@H](O)[C@@]([H])(O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@H](O7)CO)[C@@H](O6)C)[H])O)[H])O)=CO1

Molecular Formula

C36H52O15

Molecular Weight

724.79

Precautions

P260-P262-P264-P270-P271-P280-P284-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

References & Citations

[1]Laetitia Moreno Y Banuls, et al. Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na+/K+-ATPase. Mol Cancer. 2013 Apr 26:12:33.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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