JW 618

• Description:

  JW 618 is a selective ABHD6 inhibitor, with IC50s of 38 and 13 nM for mouse and rat ABHD6[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H225-H319-H336

• Target:

  MAGL

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/jw-618.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N(CC1=CC(C2=CC=NC=C2)=CC=C1)C)OC(C(F)(F)F)C(F)(F)F

• Molecular Formula:

  C17H14F6N2O2

• Molecular Weight:

  392.30

• Precautions:

  P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P370+P378-P403+P233-P403+P235-P405-P501

• References & Citations:

  [1]Chang JW, et al. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem Biol. 2012 May 25;19 (5) :579-88.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1416133-88-4