FOXP3 (3G3), 0.2mg/mL

Recognizes a protein of 47-55 kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion (amino acids 2-136) of the protein.The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

9007-83-4

JM2, AIID, DIETER, IPEX, MGC141961, MGC141963, PIDX, XPID, FOXP3delta7, forkhead box protein P3, immune dysregulation, polyendocrinopathy, enteropathy, X-linked, immunodeficiency, polyendocrinopathy, enteropathy, X-linked, scurfin

41116161

Primary and secondary antibodies for multiple methodology immunostaining detection application

FOXP3

50943

247700

Q9BZS1

Q9BZS1

FOXP3

Full-length His-tagged mouse FOXP3 protein

FOXP3

3G3

Primary

Animal

Animal

Flow, intracellular (published)

Cancer, Developmental biology, Endocrinology, Transcription factors

Tonsil, lymph node or Breast carcinoma

2 years

0.2 mg/mL

PBS, 0.05% BSA, 0.05% azide

47-55 kDa

Note: References for this clone sold by other suppliers may be listed for expected applications. PNAS USA (2006) 103(17): 6659-6664. (Flow; epitope mapping) Cytometry Part A (2009) 75A: 1040-1050. (Flow; comparison of anti-FOXP3 clones and fixation methods)

RT (ND)

Stable at room temperature or 37°C (98°F) for 7 days.

Guaranteed for at least 24 months from date of receipt when stored as recommended

IgG1, kappa

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)