GRO-alpha/CXCL1, Rat

GRO-alpha/CXCL1, Rat

• UNSPSC Description: CXCL1 (Chemokine (C-X-C motif) ligand 1), also known as GRO alpha, NAP-3 or MGSA, belongs to the sub-family of CXC chemokine. CXCL1 is involved in the development of many inflammatory diseases, including the induction of angiogenesis and recruitment of neutrophils. CXCL1 is produced by many cell types, and activates CXCR2 and, at high levels, CXCR1[1]. GRO-alpha/CXCL1 Protein, Rat is produced in E. coli, and consists of 72 amino acids (A25-N96).
• Type: Recombinant Proteins
• Assay Protocol: https://www.medchemexpress.com/cytokines/gro-alpha-cxcl1-protein-rat.html
• Purity: 97.0
• Smiles: APVANELRCQ CLQTVAGIHF KNIQSLKVMP PGPHCTQTEV IATLKNGREA CLDPEAPMVQ KIVQKMLKGV PK
• Molecular Weight: 7-11 kDa
• References & Citations: [1]Dhawan P, et al. Role of CXCL1 in tumorigenesis of melanoma. J Leukoc Biol. 2002 Jul;72(1):9-18.|[2]Jan Korbecki, et al. CXCL1: Gene, Promoter, Regulation of Expression, mRNA Stability, Regulation of Activity in the Intercellular Space. Int J Mol Sci. 2022 Jan 12;23(2):792.|[3]Sheng-Mou Hou, et al. CXCL1 contributes to IL-6 expression in osteoarthritis and rheumatoid arthritis synovial fibroblasts by CXCR2, c-Raf, MAPK, and AP-1 pathway. Arthritis Res Ther. 2020 Oct 21;22(1):251.|[4]Huey-ming Lo, et al. TNF-α induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways. Acta Pharmacol Sin. 2014 Mar;35(3):339-50.|[5]Pascale Ribaux, et al. Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells. Endocrinology. 2007 Nov;148(11):5582-90.|[6]Thamyris Reis Moraes, et al. Participation of CXCL1 in the glial cells during neuropathic pain. Eur J Pharmacol. 2020 May 15;875:173039.
• Shipping Conditions: Blue Ice
• Storage Conditions: Stored at -20°C for 2 years