Benidipine

CAT: 0804-HY-B1448ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-B1448ASize:1 Each
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Description
Benidipine is a potent and orally active calcium channel antagonist[1]. Benidipine shows anti-apoptosis effects in ischaemic/reperfused myocardial cells[2]. Benidipine increases the activity of endothelial cell-type nitric oxide synthase and improves coronary circulation in hypertensive rats[3].
CAS Number
[105979-17-7]
Product Name Alternative
KW-3049 (free base)
UNSPSC
12352005
Hazard Statement
H301
Target
Apoptosis; Calcium Channel
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/benidipine.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C)NC(C)=C(C(O[C@H]2CN(CC3=CC=CC=C3)CCC2)=O)[C@@H]1C4=CC=CC([N+]([O-])=O)=C4)OC
Molecular Formula
C28H31N3O6
Molecular Weight
505.56
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Yao K, et al. Pharmacological, pharmacokinetic, and clinical properties of benidipine hydrochloride, a novel, long-acting calcium channel blocker. J Pharmacol Sci. 2006 Apr;100 (4) :243-61.|[2]Gao F, et al. Anti-apoptotic effect of benidipine, a long-lasting vasodilating calcium antagonist, in ischaemic/reperfused myocardial cells. Br J Pharmacol. 2001 Feb;132 (4) :869-78.|[3]Kobayashi N, et al. Benidipine stimulates nitric oxide synthase and improves coronary circulation in hypertensive rats. Am J Hypertens. 1999 May;12 (5) :483-91.|[4]Masanori S, et al. Orally administered benidipine and manidipine prevent ischemia-reperfusion injury in the rat heart. Circ J. 2004 Mar;68 (3) :241-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
L-type calcium channel

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RM-B140400-01Benidipine
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RM-B140431-01Benidipine Impurity 5 ((R, R) -Benidipine)
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RM-B140401-01Benidipine Impurity A
B157495(+)-α-Benidipine Hydrochloride
TRC-D229465-250MGDehydro Benidipine
RM-B140460-01Benidipine-D7
B1409-5.1Benidipine HCl
sc-503305(-) -α-Benidipine Hydrochloride

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