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FOXO1-IN-3

CAT: 0804-HY-153617-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153617-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FOXO1-IN-3 is a highly-selective and orally active FOXO1 inhibitor. FOXO1-IN-3 reduces hepatic glucose production in mice. FOXO1-IN-3 improves insulin sensitivity and glucose control in db/db mice without causing weight gain[1].
CAS Number
2451093-95-9
UNSPSC
12352005
Target
FOXO
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/foxo1-in-3.html
Purity
99.47
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(N2CCN(CC2)C)C=C1)NC3=CC(C4=NC5=C(N4)C=CC=C5)=NN3
Molecular Formula
C22H23N7O
Molecular Weight
401.46
References & Citations
[1]Lee YK, et al. FOXO1 inhibition synergizes with FGF21 to normalize glucose control in diabetic mice. Mol Metab. 2021 Jul;49:101187.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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