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BI1543673

CAT: 0804-HY-169057Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169057Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BI1543673 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor. BI1543673 can reduce the inflammatory response stimulated by TLR4 and TLR7/8 in human lung tissue. BI1543673 can decrease inflammatory signaling in a mouse model of lung inflammation induced by LPS[1].
UNSPSC
12352005
Target
IRAK; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bi1543673.html
Smiles
CC1=CN2N=CC(C(NC3=NC4=C(N3CC(C)(O)C)C=CC([C@H]5CC[C@H](CC5)N6CCCC6)=C4)=O)=C2N=C1
Molecular Formula
C29H37N7O2
Molecular Weight
515.65
References & Citations
[1]Sayers I, et al. Interleukin-1 receptor-associated kinase 4 (IRAK4) is a critical regulator of inflammatory signalling through toll-like receptors 4 and 7/8 in murine and human lungs. Br J Pharmacol. 2024 Aug 13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR4; TLR7; TLR8

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CatalogName
T200483-01BI1543673

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