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Cyclin D1 (DCS-6), 1mg/mL

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Description
Recognizes a protein of 36 kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t (11; 14) (q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative) . About 40% of breast carcinomas are positive for Cyclin D1. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
CAS Number
9007-83-4
Synonyms
B cell CLL/lymphoma 1; B cell leukemia 1; B-cell lymphoma 1 protein; BCL-1 oncogene; CCND1 protein; CCND1/FSTL3 fusion gene; CCND1/IGHG1 fusion gene CCND1/IGLC1 fusion gene; CCND1/PTH fusion gene; G1/S-specific cyclin-D1; Parathyroid adenomatosis 1; PRAD1 oncogene
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
CCND1
Gene ID
595
NCBI Gene ID
523852; 667996
UniProt
P24385
Swiss Prot
P24385
Host
Mouse
Species Reactivity
Human, Monkey, Mouse, Rat
Reactivity
Cyclin D1
Immunogen
Human full length recombinant cyclin D1 protein
Target Antigen
Cyclin D1
Clonality
Monoclonal
Clone
DCS-6
Type
Primary
Source
Animal
Origin
Animal
Applications
Flow, intracellular (verified) |IHC, FFPE (verified) |WB (verified)
Field of Research
Cancer, Cell cycle
Positive Control
T47D, ZR75, BT474, SKBR3, MCF-7, MDA-MB-453, HT29, Ramos, Jurkat or A431 cells. Mantle cell lymphoma, breast or bladder carcinomas.
Stability
2 years
Concentration
1 mg/mL
Buffer
PBS, no BSA, no azide
Molecular Weight
36 kDa
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG2a, kappa
Species
Mus musculus (mouse)
Classification
PBS, no BSA, no sodium azide (CAS 26628-22-8)
Conjugate
Purified, BSA-free

UniProtKB · P24385

G1/S-specific cyclin-D1

CCND1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P24385
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CCND1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q6LEF0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Cell cycleCell divisionDNA damageTranscriptionTranscription regulation

Coding sequence diversity

Chromosomal rearrangement

Molecular function

CyclinRepressor

Cellular component

CytoplasmMembraneNucleus

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Disease

Proto-oncogene
Product Datasheet
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NBP3-30975-100ugMouse Monoclonal Cyclin D1 Antibody (DCS-6)
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