Thalidomide-Propargyne-PEG1-COOH
CAT:
804-HY-138778-03
Size:
100 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Thalidomide-Propargyne-PEG1-COOH
- CAS Number: 2828438-36-2
- UNSPSC Description: Thalidomide-Propargyne-PEG1-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. Thalidomide-Propargyne-PEG1-COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Target Antigen: Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
- Type: Reference compound
- Related Pathways: Apoptosis;Autophagy;PROTAC
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/thalidomide-propargyne-peg1-cooh.html
- Smiles: OC(CCOCC#CC(C=C12)=CC=C2C(N(C1=O)C3CCC(NC3=O)=O)=O)=O
- Molecular Weight: 384.34
- References & Citations: [1]Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-990.
- Shipping Conditions: Blue Ice