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Nalanthalide

CAT: 0804-HY-N8372Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N8372Size:1 Each
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Description
Nalanthalide is a voltage-gated potassium channel Kv1.3 blocker (IC50=3.9 µM) and a potential immunosuppressant. Nalanthalide can be used for research on inflammatory immune diseases, such as neuroinflammation[1][2].
CAS Number
145603-76-5
UNSPSC
12352005
Target
Potassium Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nalanthalide.html
Solubility
10 mM in DMSO
Smiles
O=C1C(C[C@@H]2C(CC[C@@]3([H])[C@@](CC/C=C(C)/C)(C)[C@@H](OC(C)=O)CC[C@]23C)=C)=C(OC)OC(C)=C1C
Molecular Formula
C30H44O5
Molecular Weight
484.67
References & Citations
[1]Singh SB, et al. Candelalides A-C: novel diterpenoid pyrones from fermentations of Sesquicillium candelabrum as blockers of the voltage-gated potassium channel Kv1.3. Org Lett. 2001 Jan 25;3 (2) :247-50.|[2]Michael A Goetz, et al. Diterpenoid pyrones, novel blockers of the voltage-gated potassium channel Kv1.3 from fungal fermentations. Tetrahedron Lett. 2001Feb 12;42 (7) :1255-1257.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
VFA60376-01Nalanthalide

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