CD70 (BU69), 0.2mg/mL

CAT: 0037-BNUB0187-100Size: 1x 100 µLDry Ice: NoHazardous: No
CAT#:0037-BNUB0187-100Size:1x 100 µL
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Description
This antibody recognizes a protein of 30 kDa, identified as CD70. It is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T- and B-lymphocytes. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. This MAb blocks the interaction between CD27 and CD70, and has been shown toinhibit T cell proliferation induced by dendritic cells.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
CAS Number
9007-83-4
Synonyms
CD27 ligand (CD27L) ; CD27LG; Ki24; Surface antigen CD70; Tumor necrosis factor (ligand) superfamily, member 7 (TNFSF7)
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
CD70
Gene ID
970
NCBI Gene ID
501497; 715224
UniProt
P32970
Swiss Prot
P32970
Host
Mouse
Species Reactivity
Human
Reactivity
CD70
Immunogen
Human WM-1 (Waldenstrom s macroglobulinemia) cell line
Target Antigen
CD70
Clonality
Monoclonal
Clone
BU69
Type
Primary
Source
Animal
Origin
Animal
Applications
Flow, surface (published) |Functional studies (published)
Field of Research
Cytokines, Immunology
Positive Control
Raji cells. Lymph node or tonsil.
Stability
2 years
Concentration
0.2 mg/mL
Buffer
PBS, 0.05% BSA, 0.05% azide
Molecular Weight
~30 kDa
References & Citations
Note: References for this clone sold by other suppliers may be listed for expected applications. Lymphology (2003) 36: 74-83. (Flow) J Immunol (2006) 176:7726-7735. (functional studies) Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1137-1138.
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG1, kappa
Species
Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)
Conjugate
Purified, with BSA
Product Datasheet
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