CD70 (BU69), 0.2mg/mL

• Description :

  This antibody recognizes a protein of 30 kDa, identified as CD70. It is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T- and B-lymphocytes. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. This MAb blocks the interaction between CD27 and CD70, and has been shown toinhibit T cell proliferation induced by dendritic cells.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

• CAS Number :

  9007-83-4

• Synonyms :

  CD27 ligand (CD27L) ; CD27LG; Ki24; Surface antigen CD70; Tumor necrosis factor (ligand) superfamily, member 7 (TNFSF7)

• UNSPSC :

  41116161

• UNSPSC Description :

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene Name :

  CD70

• Gene ID :

  970

• NCBI Gene ID :

  501497; 715224

• UniProt :

  P32970

• Swiss Prot :

  P32970

• Host :

  Mouse

• Species Reactivity :

  Human

• Reactivity :

  CD70

• Immunogen :

  Human WM-1 (Waldenstrom s macroglobulinemia) cell line

• Target Antigen :

  CD70

• Clonality :

  Monoclonal

• Clone :

  BU69

• Type :

  Primary

• Source :

  Animal

• Origin :

  Animal

• Applications :

  Flow, surface (published) |Functional studies (published)

• Field of Research :

  Cytokines, Immunology

• Positive Control :

  Raji cells. Lymph node or tonsil.

• Stability :

  2 years

• Concentration :

  0.2 mg/mL

• Buffer :

  PBS, 0.05% BSA, 0.05% azide

• Molecular Weight :

  ~30 kDa

• References & Citations :

  Note: References for this clone sold by other suppliers may be listed for expected applications. Lymphology (2003) 36: 74-83. (Flow) J Immunol (2006) 176:7726-7735. (functional studies) Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1137-1138.

• Shipping Conditions :

  RT (ND)

• Storage Conditions :

  Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life :

  Guaranteed for at least 24 months from date of receipt when stored as recommended

• Fragment :

  IgG1, kappa

• Species :

  Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

• Classification :

  PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)

• Conjugate :

  Purified, with BSA