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SN40

CAT: 0804-HY-146241-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-146241-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SN40 is a potent amino acid transport (AAT) inhibitor with Kis of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM and 5.55 μM for rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. SN40 can be used for researching anticancer[1].
CAS Number
2768663-14-3
UNSPSC
12352005
Target
ASCT; EAAT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sn40.html
Purity
99.26
Solubility
DMSO : 10 mg/mL (ultrasonic; adjust pH to 2 with 1M HCl)
Smiles
OC([C@@H](NC1)C[C@@H]1NCC2=CC=C(C3=CC=CC=C3)C=C2)=O
Molecular Formula
C18H20N2O2
Molecular Weight
296.36
References & Citations
[1]Grewer Christof, et al. Preparation of amino acids as inhibitors of alanine serine cysteine transporter 2. World Intellectual Property Organization, WO2022087630 A1 2022-04-28
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ASCT2; EAAT1; EAAT2; EAAT3; EAAT5

Chemical Information

CID 164516873
CAS Number2768663-14-3
PubChem CID164516873
IUPAC Name(2S,4S)-4-[(4-phenylphenyl)methylamino]pyrrolidine-2-carboxylic acid
Molecular FormulaC18H20N2O2
Molecular Weight296.4
XLogP0
Topological Polar Surface Area61.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Heavy Atom Count22
Formal Charge0
Complexity360
SMILES
C1[C@@H](CN[C@@H]1C(=O)O)NCC2=CC=C(C=C2)C3=CC=CC=C3
InChI
InChI=1S/C18H20N2O2/c21-18(22)17-10-16(12-20-17)19-11-13-6-8-15(9-7-13)14-4-2-1-3-5-14/h1-9,16-17,19-20H,10-12H2,(H,21,22)/t16-,17-/m0/s1
InChIKey
FKDKNHWXEJUEMP-IRXDYDNUSA-N
Chemical Structure
2D Structure
2D structure of CID 164516873
CAS: 2768663-14-3
CID: 164516873
Formula: C18H20N2O2
MW: 296.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight296.4
XLogP30
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass296.152477885
Monoisotopic Mass296.152477885
Topological Polar Surface Area61.4 Ų
Heavy Atom Count22
Formal Charge0
Complexity360
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA6646-5SN40
C8519-5SN40 hydrochloride

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