Nitrofurazone

Nitrofurazone

• CAS Number: 59-87-0
• UNSPSC Description: Nitrofurazone (Nitrofural) is a broad spectrum antibiotic that has oral activity. Nitrofurazone is a nitro-aromatic drug. Nitrofurazone is active against both Gram-positive and Gram-negative bacteria[1][2][3][4][5].
• Target Antigen: Antibiotic; Bacterial
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/Nitrofurazone.html
• Purity: 99.86
• Solubility: DMSO : ≥ 155 mg/mL
• Smiles: O=C(N/N=C/C1=CC=C([N+]([O-])=O)O1)N
• Molecular Weight: 198.14
• References & Citations: [1]Ryan A, et al. Activation of nitrofurazone by azoreductases: multiple activities in one enzyme. Sci Rep. 2011;1:63.|[2]McCalla DR, et al. Mode of action of nitrofurazone. J Bacteriol. 1970 Dec;104(3):1126-34.|[3]Tu Y, et al. Effect of nitrofurazone on bacterial RNA and ribosome synthesis and on the function of ribosomes. Chem Biol Interact. 1976 Jul;14(1-2):81-91.|[4]Z Kari FW, et al. Toxicity and carcinogenicity of nitrofurazone in F344/N rats and B6C3F1 mice. Food Chem Toxicol. 1989 Feb;27(2):129-37.|[5]Neal RA, et al. The activity of nitrofurazone and furazolidone against Leishmania donovani, L. major and L. enriettii in vitro and in vivo. Ann Trop Med Parasitol. 1988 Oct;82(5):453-6.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched