Anti-CD5 (Mantle Cell Lymphoma Marker)(B-B8)
CAT:
37-BNUM0995-50
Size:
50 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anti-CD5 (Mantle Cell Lymphoma Marker)(B-B8)
- Description: This antibody recognizes a 67 kDa transmembrane protein which is identified as CD5. The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (~10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a diagnosis of mature T-cell neoplasms. Note that this MAb is not suitable for frozen tissues.
- Synonyms: CD5 antigen (p56 62), LEU1, Ly12, LyA, Lymphocyte antigen T1/Leu-1, Lymphocyte glycoprotein T1/Leu1, T-cell surface glycoprotein CD5
- CAS Number: 9007-83-4
- UNSPSC: 41116161
- UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
- Gene Name: CD5
- Gene ID: 921
- NCBI Gene ID: 58685
- UniProt: P06127
- Cellular Locus: Plasma membrane
- Host: Mouse
- Species Reactivity: Human
- Immunogen: T cells activated with PHA
- Target Antigen: CD5
- Clonality: Monoclonal
- Isotype: IgG1 κ
- Clone: B-B8
- Conjugation: Purified, BSA-free
- Disease: Tumor
- Source: Animal
- Applications: Functional studies (published) | Flow, surface (expected) | IF (expected)
- Validated Applications: FC, IF
- Field of Research: Immunology
- Positive Control: 293T, Ramos, or MOLT-4 Cells. Tonsil.
- Concentration: 1 mg/mL
- Buffer: PBS, no BSA, no azide
- Molecular Weight: 67 kDa
- Additionnal Information: Not suitable for frozen tissues|Flow cytometry: 0.5-1 ug/million cells|Immunofluorescence: 0.5-1 ug/mL|Optimal dilution for a specific application should be determined by user
- References & Citations: Note: References for this clone sold by other suppliers may be listed for expected applications. Inf Immunity (1996) 64(5): 1595-1599. (cell depletion) Br J Haematol (2013) 163: 182-193. (antibody internalization)
- Shipping Conditions: Room temperature
- Storage Conditions: -35°C to -5°C ; Stable at room temperature or 37°C (98°F) for 7 days.
- Shelf Life: 2 years