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4-Hydroxylonchocarpin

CAT: 0804-HY-N2208-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2208-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4-Hydroxylonchocarpin is a chalcone compound. 4-Hydroxylonchocarpin enhances the phosphorylation of p38 MAPK, JNK and ERK. 4-Hydroxylonchocarpin induces reactive oxygen species (ROS) and apoptosis in liver cancer cells. 4-Hydroxylonchocarpin has various pharmacological activities, including antibacterial, anticancer, anti-retroviral, anti-tuberculosis, anti-malarial and anti-inflammatory activities[1][2].
CAS Number
56083-03-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; p38 MAPK; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Infection; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/4-hydroxylonchocarpin.html
Purity
99.28
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C2C(C=CC(C)(C)O2)=C1O)/C=C/C3=CC=C(O)C=C3
Molecular Formula
C20H18O4
Molecular Weight
322.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Lim J, et al. Antimelanogenic effect of 4-hydroxylonchocarpin through the inhibition of tyrosinase-related proteins and MAPK phosphatase. Exp Dermatol. 2016 Jul;25 (7) :574-6.|[2]Ouyang L, et al. 4-hydroxylonchocarpin and corylifol A: The potential hepatotoxic components of Psoralea corylifolia L. Toxicol Lett. 2023 Aug 15;385:31-41.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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