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Sappanone A

CAT: 0804-HY-113556-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113556-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sappanone A is an orally active homoisoflavone found in sappan L. Sappanone A is a PDE4 and NF-κB inhibitor with anti-inflammatory and antioxidant effect. Sappanone A induces HO-1 expression through activation of Nrf2 pathway. Sappanone A also inhibits RANKL-induced osteoclastogenesis. Sappanone A has great potential in the research of inflammation-related and cardiovascular [1][2][3][4][5].
CAS Number
102067-84-5
UNSPSC
12352005
Target
Akt; COX; ERK; Interleukin Related; JNK; Keap1-Nrf2; NF-κB; NO Synthase; Nuclear Factor of activated T Cells (NFAT) ; p38 MAPK; Phosphodiesterase (PDE) ; Reactive Oxygen Species (ROS) ; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sappanone-a.html
Concentration
10mM
Purity
99.87
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1/C(COC2=CC(O)=CC=C12)=C/C3=CC=C(O)C(O)=C3
Molecular Formula
C16H12O5
Molecular Weight
284.26
References & Citations
[1]Lee S, et, al. Sappanone A exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. Int Immunopharmacol. 2015 Sep;28 (1) :328-36. |[2]Wang YZ, et al. Sappanone A: A natural PDE4 inhibitor with dual anti-inflammatory and antioxidant activities from the heartwood of Caesalpinia sappan L. J Ethnopharmacol. 2023 Mar 25;304:116020.|[3]Choo YY, et al. Sappanone A inhibits RANKL-induced osteoclastogenesis in BMMs and prevents inflammation-mediated bone loss. Int Immunopharmacol. 2017 Nov;52:230-237. |[4]Shi X, et al. Sappanone A Protects Against Myocardial Ischemia Reperfusion Injury by Modulation of Nrf2. Drug Des Devel Ther. 2020 Jan 8;14:61-71.|[5]Wang Z, et al. Sappanone a prevents diabetic kidney disease by inhibiting kidney inflammation and fibrosis via the NF-κB signaling pathway. Front Pharmacol. 2022 Aug 16;13:953004.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
465858-01Sappanone A
MBS5791923Sappanone B
A24111-10Sappanone A 10mg
A24111-100Sappanone A 100mg
A24111-50Sappanone A 50mg
A24111-5Sappanone A 5mg

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