Dihydrostreptomycin

• Description :

  Dihydrostreptomycin (DHSM) is an aminoglycoside antibiotic with antibacterial effect against Gram-negative bacteria. Dihydrostreptomycin exhibits ototoxicity that causes irreversible damage in inner ear hair cells, leading to hearing loss[1].

• Product Name Alternative :

  DHSM

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H312-H332

• Target :

  Antibiotic; Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/dihydrostreptomycin.html

• Smiles :

  CN[C@H]1[C@@H]([C@H]([C@@H](O[C@@]1(C)O[C@H]2[C@H](O[C@H]([C@@]2(CO)O)C)O[C@@]3(C)[C@@H]([C@H]([C@@H]([C@H]([C@@H]3NC(N)=N)O)NC(N)=N)O)O)CO)O)O

• Molecular Formula :

  C23H45N7O12

• Molecular Weight :

  611.64

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

• References & Citations :

  [1]Marcotti W, et al. The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels. J Physiol. 2005 Sep 1;567 (Pt 2) :505-21.|[2]Yamashita H, et al., Cell proliferation in spiral ligament of mouse cochlea damaged by dihydrostreptomycin sulfate. Acta Otolaryngol. 1999;119 (3) :322-5.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [128-46-1]