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Dihydrostreptomycin

CAT: 0804-HY-B1241ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B1241ASize:1 Each
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Description
Dihydrostreptomycin (DHSM) is an aminoglycoside antibiotic with antibacterial effect against Gram-negative bacteria. Dihydrostreptomycin exhibits ototoxicity that causes irreversible damage in inner ear hair cells, leading to hearing loss[1].
CAS Number
128-46-1
Product Name Alternative
DHSM
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dihydrostreptomycin.html
Smiles
CN[C@H]1[C@@H]([C@H]([C@@H](O[C@@]1(C)O[C@H]2[C@H](O[C@H]([C@@]2(CO)O)C)O[C@@]3(C)[C@@H]([C@H]([C@@H]([C@H]([C@@H]3NC(N)=N)O)NC(N)=N)O)O)CO)O)O
Molecular Formula
C23H45N7O12
Molecular Weight
611.64
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Marcotti W, et al. The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels. J Physiol. 2005 Sep 1;567 (Pt 2) :505-21.|[2]Yamashita H, et al., Cell proliferation in spiral ligament of mouse cochlea damaged by dihydrostreptomycin sulfate. Acta Otolaryngol. 1999;119 (3) :322-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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