Products for Research Use Only
RegisterLogin

CD46 (169-1-E4.3), 0.2mg/mL

CAT: 0037-BNUB0930-500Size: 1x 500 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0037-BNUB0930-500Size:1x 500 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Recognizes a protein of 52 kDa-58 kDa, identified as CD46 (also known as membrane cofactor protein, MCP) . Its epitope is located on the four immunogenic short consensus repeat (SCR) domains at N-terminus of the protein. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
CAS Number
9007-83-4
Synonyms
AHUS2; Complement membrane cofactor protein; MCP; Measles virus receptor; Membrane cofactor protein; MIC10; TLX; Trophoblast leucocyte common antigen; Trophoblast lymphocyte cross reactive antigen
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
CD46
Gene ID
4179
NCBI Gene ID
510402
UniProt
P15529
Swiss Prot
P15529
Host
Mouse
Species Reactivity
Baboon, Human
Reactivity
CD46
Immunogen
Stimulated human leukocytes
Target Antigen
CD46
Clonality
Monoclonal
Clone
169-1-E4.3
Type
Primary
Source
Animal
Origin
Animal
Applications
Flow, surface (published) |IHC, FFPE (published) |Functional studies (published)
Field of Research
Immunology
Positive Control
K562, U937, HL60, HeLa and Jurkat cells, and human lymphocytes. Lymph node and tonsil.
Stability
2 years
Concentration
0.2 mg/mL
Buffer
PBS, 0.05% BSA, 0.05% azide
Molecular Weight
52-58 kDa
References & Citations
Note: References for this clone sold by other suppliers may be listed for expected applications. Anticancer Res (2006) 26: 4943-4948. (IHC, FFPE) Virology (2017) 502: 160-170. (functional studies) Virology (2010) 405(2), 474-482.
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG2a, kappa
Species
Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)
Conjugate
Purified, with BSA
Product Datasheet
Loading...
Product MSDS
Loading...

Related Products

CatalogName
BNUM0930-50CD46 (169-1-E4.3), 1mg/mL
BNC400930-100CD46 (169-1-E4.3), CF640R conjugate, 0.1mg/mL
BNC740930-100CD46 (169-1-E4.3), CF740 conjugate, 0.1mg/mL
BNC940930-100CD46 (169-1-E4.3), CF594 conjugate, 0.1mg/mL
BNC940930-500CD46 (169-1-E4.3), CF594 conjugate, 0.1mg/mL
BNC680930-100CD46 (169-1-E4.3), CF568 conjugate, 0.1mg/mL
BNC740930-500CD46 (169-1-E4.3), CF740 conjugate, 0.1mg/mL
BNC880930-100CD46 (169-1-E4.3), CF488A conjugate, 0.1mg/mL
BNCB0930-500CD46 (169-1-E4.3), Biotin conjugate, 0.1mg/mL
BNC680930-500CD46 (169-1-E4.3), CF568 conjugate, 0.1mg/mL

Alternative Products

CatalogName
IRBAMLCD46AP395200ULRabbit Anti CD46 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Western Blot)
MBS8423138-01Rabbit Anti CD46 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3)(Western Blot)
IRBAHUCD46AP093120ULRabbit Anti Human CD46 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Western Blot,Immunofluorescence) 120ul
IRBAHUCD46AP093200ULRabbit Anti Human CD46 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Western Blot,Immunofluorescence) 200ul
sc-7634CD46 (E4.3)
36-2757-20Anti-CD46 (Membrane Cofactor Protein) Monoclonal Antibody (Clone: 169-1-E4.3)
sc-7634 FITCCD46 (E4.3) FITC
sc-7634 HRPCD46 (E4.3) HRP
sc-7634 ACCD46 (E4.3) AC
sc-7634 PECD46 (E4.3) PE

Popular Products