Anti-CD46(122.2)

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Anti-CD46(122.2)

CAT:

37-BNUB0175-100

Size:

100 µL

Price:

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For price, please contact [email protected].

Anti-CD46(122.2)

Description: CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4 into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Synonyms: AHUS2; Complement membrane cofactor protein; MCP; Measles virus receptor; Membrane cofactor protein; MIC10; TLX; Trophoblast leucocyte common antigen; Trophoblast lymphocyte cross reactive antigen
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: CD46
Gene ID: 4179
NCBI Gene ID: 510402
UniProt: P15529
Cellular Locus: Plasma membrane
Host: Mouse
Species Reactivity: Human
Immunogen: Recombinant human CD46 protein
Target Antigen: CD46
Clonality: Monoclonal
Isotype: IgG1 κ
Clone: 122.2
Conjugation: Purified, with BSA
Source: Animal
Applications: Flow (verified) | Flow, surface (published)
Validated Applications: FC, FC,
Field of Research: Immunology
Positive Control: HeLa, K-562 or MOLT-4 cells. Kidney
Concentration: 0.2 mg/mL
Buffer: PBS, 0.05% BSA, 0.05% azide
Molecular Weight: 56-66 kDa
Additionnal Information: Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Immunofluorescence: 0.5-1 ug/mL|Flow Cytometry 0.5-1 ug/million cells/0.1 mL|Optimal dilution for a specific application should be determined by user
References & Citations: Note: References for this clone sold by other suppliers may be listed for expected applications. Virology (2002) 300: 160-169. (Flow, surface)
Shipping Conditions: Room temperature
Storage Conditions: 4°C; Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: 2 years

Complementary Product Range

Our range of products, including Anti-CD46(122.2), falls within the same field of application and can be used across various research projects. These products are carefully selected for their high performance and reliability, supporting the diverse needs of modern laboratories. Whether for ongoing studies or future experiments, they are designed to help researchers achieve their scientific goals. Here are some related products that may be of interest for similar or future applications:

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Cat	Name
BNUB0175-500	Anti-CD46(122.2)
BNUM0175-50	Anti-CD46(122.2)
BNUB0175-100	Anti-CD46(122.2)
BNC040175-100	Anti-CD46(122.2), CF405S conjugate
BNC400175-100	Anti-CD46(122.2), CF640R conjugate
BNC470175-100	Anti-CD46(122.2), CF647 conjugate
BNC880175-500	Anti-CD46(122.2), CF488A conjugate
BNCB0175-100	Anti-CD46(122.2), Biotin conjugate
BNC680175-500	Anti-CD46(122.2), CF568 conjugate
BNC880175-100	Anti-CD46(122.2), CF488A conjugate