CD45RA (PTPRC/818), 0.2mg/mL

Recognizes a protein of 205 kDa-220 kDa, identified as CD45RA (Workshop III) . CD45RA is isoforms of the human leukocyte common antigen (CD45) . Human CD45 contains three exons which encode peptide segments designated A, B and C, respectively. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4 T-cells, 50% of peripheral CD8 T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin T-cells. T-cells expressing CD45RO are memory T-cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. This MAb is useful in study on the subpopulation of CD4 or CD8 T-cells. It can especially be used to differentiate T-cell lymphomas (CD45RO positive) from B cell lymphomas (CD45RA positive) .Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

9007-83-4

B220, CD45R, GP180, Leukocyte common antigen (LCA), Loc, Ly-5, Lyt-4, Protein tyrosine phosphatase receptor type C (PTPRC), Receptor-type tyrosine-protein phosphatase C, T200 glycoprotein

41116161

Primary and secondary antibodies for multiple methodology immunostaining detection application

PTPRC

5788

654514

P08575

P08575

CD45RA

Recombinant full-length human CD45RA protein

CD45RA

PTPRC/818

Primary

Animal

Animal

Flow (verified) |IF (verified) |IHC, FFPE (verified) |WB (verified)

Immunology, Signal transduction

Daudi, Raji, IM9 and human lymphocytes. Human lymph nodes and tonsils.

2 years

0.2 mg/mL

PBS, 0.05% BSA, 0.05% azide

205-220 kDa

RT (ND)

Stable at room temperature or 37°C (98°F) for 7 days.

Guaranteed for at least 24 months from date of receipt when stored as recommended

IgG2a, kappa

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)