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Diuron

CAT: 0804-HY-B0860-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0860-01Size:500 mg
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Description
Diuron is an orally active phenylurea herbicide. Diuron inhibits photosynthesis in plants by blocking the formation of ATP and NADH. Diuron increases the production of ROS. Diuron increases expression of p53 in certain cell lines. Diuron has herbicidal activity against annual and perennial broadleaf weeds and grass weeds. Diuron promotes DMBA/BBN-induced bladder cancer. Diuron can be used in breast cancer research[1][2][3][4][5][6].
CAS Number
[330-54-1]
UNSPSC
12352005
Hazard Statement
H302, H351, H373, H410
Target
Herbicide; MDM-2/p53; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/diuron.html
Concentration
10mM
Purity
99.08
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(Cl)C(Cl)=C1)N(C)C
Molecular Formula
C9H10Cl2N2O
Molecular Weight
233.10
Precautions
H302, H351, H373, H410
References & Citations
[1]Huovinen M, et al. Toxicity of diuron in human cancer cells. Toxicol In Vitro. 2015 Oct;29 (7) :1577-86.|[2]Lundegårdh H. THE INFLUENCE OF DIURON (3- (3,4-DICHLOROPHENYL) -1,1-DIMETHYLUREA) ON THE RESPIRATORY AND PHOTOSYNTHETIC SYSTEMS OF PLANTS. Proc Natl Acad Sci U S A. 1965 Apr;53 (4) :703-10.|[3]Da Rocha MS, et al. Diuron-induced rat urinary bladder carcinogenesis: mode of action and human relevance evaluations using the International Programme on Chemical Safety framework. Crit Rev Toxicol. 2014 May;44 (5) :393-406.|[4]Chauhan L K S, et al. Diuron-induced cytological and ultrastructural alterations in the root meristem cells ofAllium cepa. Pesticide Biochemistry and Physiology, 1998, 62 (3) : 152-163.|[5]Da Rocha MS, et al. Diuron-induced rat bladder epithelial cytotoxicity. Toxicol Sci. 2012 Dec;130 (2) :281-8.|[6]de Moura NA, et al. Potential effects of the herbicide Diuron on mammary and urinary bladder two-stage carcinogenesis in a female Swiss mouse model. Arch Toxicol. 2010 Feb;84 (2) :165-73.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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