Diuron

• Description:

  Diuron is an orally active phenylurea herbicide. Diuron inhibits photosynthesis in plants by blocking the formation of ATP and NADH. Diuron increases the production of ROS. Diuron increases expression of p53 in certain cell lines. Diuron has herbicidal activity against annual and perennial broadleaf weeds and grass weeds. Diuron promotes DMBA/BBN-induced bladder cancer. Diuron can be used in breast cancer research[1][2][3][4][5][6].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H351, H373, H410

• Target:

  Herbicide; MDM-2/p53; Reactive Oxygen Species (ROS)

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/diuron.html

• Concentration:

  10mM

• Purity:

  99.08

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  O=C(NC1=CC=C(Cl)C(Cl)=C1)N(C)C

• Molecular Formula:

  C9H10Cl2N2O

• Molecular Weight:

  233.10

• Precautions:

  H302, H351, H373, H410

• References & Citations:

  [1]Huovinen M, et al. Toxicity of diuron in human cancer cells. Toxicol In Vitro. 2015 Oct;29 (7) :1577-86.|[2]Lundegårdh H. THE INFLUENCE OF DIURON (3- (3,4-DICHLOROPHENYL) -1,1-DIMETHYLUREA) ON THE RESPIRATORY AND PHOTOSYNTHETIC SYSTEMS OF PLANTS. Proc Natl Acad Sci U S A. 1965 Apr;53 (4) :703-10.|[3]Da Rocha MS, et al. Diuron-induced rat urinary bladder carcinogenesis: mode of action and human relevance evaluations using the International Programme on Chemical Safety framework. Crit Rev Toxicol. 2014 May;44 (5) :393-406.|[4]Chauhan L K S, et al. Diuron-induced cytological and ultrastructural alterations in the root meristem cells ofAllium cepa. Pesticide Biochemistry and Physiology, 1998, 62 (3) : 152-163.|[5]Da Rocha MS, et al. Diuron-induced rat bladder epithelial cytotoxicity. Toxicol Sci. 2012 Dec;130 (2) :281-8.|[6]de Moura NA, et al. Potential effects of the herbicide Diuron on mammary and urinary bladder two-stage carcinogenesis in a female Swiss mouse model. Arch Toxicol. 2010 Feb;84 (2) :165-73.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [330-54-1]