Anti-CD33(WM53)

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Product Documents

Datasheet

MSDS

Alternative Products

Cat	Name
MBS4160918-01	Anti-CD33 Antibody (WM53)
MBS4160918-02	Anti-CD33 Antibody (WM53)
MBS375158-01	Mouse Anti-Human CD33 [WM53]
MBS375158-02	Mouse Anti-Human CD33 [WM53]
MBS375158-03	Mouse Anti-Human CD33 [WM53]
AMM00203G	Monoclonal CD33 Antibody [Clone WM53], Clone: WM53
AMM00204G	Monoclonal CD33 Antibody [Clone WM53], Clone: WM53
E-AB-F1266A-06	Purified Anti-Human CD33 Antibody[WM53]
E-AB-F1266A-05	Purified Anti-Human CD33 Antibody[WM53]
E-AB-F1266A-01	Purified Anti-Human CD33 Antibody[WM53]

Anti-CD33(WM53)

CAT:

37-BNUM0166-50

Size:

50 µL

Price:

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For price, please contact [email protected].

Anti-CD33(WM53)

Description: Recognizes a 67 kDa glycoprotein, which is identified as CD33 (HLDA IV; WS Code M-505). CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immuno-receptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Synonyms: gp67; My9; Myeloid cell surface antigen CD33; p67; Sialic acid-binding Ig-like lectin 3 (SIGLEC3)
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: CD33
Gene ID: 945
NCBI Gene ID: 83731
UniProt: P20138
Cellular Locus: Plasma membrane
Host: Mouse
Species Reactivity: Human
Immunogen: Human AML cells
Target Antigen: CD33
Clonality: Monoclonal
Isotype: IgG1 κ
Clone: WM53
Conjugation: Purified, BSA-free
Disease: Tumor
Source: Animal
Applications: Flow, surface (published) | IHC, FFPE (published)
Validated Applications: FC, IHC, FFPE
Field of Research: Immunology
Positive Control: Human dendritic and mast cells. Human lymph nodes and tonsils.
Concentration: 1 mg/mL
Buffer: PBS, no BSA, no azide
Molecular Weight: 67 kDa
Additionnal Information: Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Immunofluorescence: 0.5-1 ug/mL|Flow Cytometry 0.5-1 ug/million cells/0.1 mL
References & Citations: Note: References for this clone sold by other suppliers may be listed for expected applications. Immunity (2002) 17(3), 289-301. (Flow) J Leukicyte Biol (2006) 79(1), 46-58. (Flow, IP) OncoImmunology, 7:4, DOI: 10.1080/2162402X.2017.1397248 (immunohistochemistry) Glycobiology (2011) 21(6), 757-770 (epitope mapping)
Shipping Conditions: Room temperature
Storage Conditions: -35°C to -5°C ; Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: 2 years

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Find us on

Cat	Name
BNUB0166-100	Anti-CD33(WM53)
BNUM0166-50	Anti-CD33(WM53)
BNUB0166-500	Anti-CD33(WM53)
BNC740166-100	Anti-CD33(WM53), CF740 conjugate
BNC470166-500	Anti-CD33(WM53), CF647 conjugate
BNC680166-500	Anti-CD33(WM53), CF568 conjugate
BNC940166-100	Anti-CD33(WM53), CF594 conjugate
BNC740166-500	Anti-CD33(WM53), CF740 conjugate
BNC040166-100	Anti-CD33(WM53), CF405S conjugate
BNC400166-500	Anti-CD33(WM53), CF640R conjugate