Anti-CD26(202-36), Biotin conjugate

Anti-CD26(202-36), Biotin conjugate

• Description: Recognizes a glycoprotein of 110 kDa, identified as CD26 (Workshop VI; Code: N-L039). It is an atypical serine protease belonging to the prolyl oligopeptidase family. It is expressed on lymphocyte cells and is upregulated during T-cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection. Cross-linking of CD26 using this antibody dramatically enhances the anti-CD3-induced IL-2 production. In Western blotting, this MAb reacts with only glycosylated CD26, but not with the deglycosylated form. It does not prevent ADA binding to CD26.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
• Synonyms: ADA-binding protein (ADABP); Adenosine deaminase complexing protein 2 (ADCP-2); Dipeptidyl peptidase 4; Dipeptidyl peptidase 4 soluble form; Dipeptidyl peptidase IV membrane form; Dipeptidyl peptidase IV soluble form; Dipeptidyl peptidase, intestinal; Dipeptidylpeptidase 4; Dipeptidylpeptidase IV; DPP4; DPPIV; Intestinal dipeptidyl peptidase; T-cell activation antigen CD26; TP103
• UNSPSC: 41116161
• UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
• Gene Name: DPP4
• Gene ID: 1803
• NCBI Gene ID: 368912
• UniProt: P27487
• Cellular Locus: Plasma membrane
• Host: Mouse
• Species Reactivity: Human, Rat
• Immunogen: Human T cell clone
• Target Antigen: CD26
• Clonality: Monoclonal
• Isotype: IgG2b κ
• Clone: 202-36
• Conjugation: Biotin
• Source: Animal
• Applications: Flow, surface (published) | Functional studies (published) | IF (published)
• Validated Applications: FC, IF
• Field of Research: Immunology
• Positive Control: YT, HEP-G2 cells, and lymphocytes. Lymph nodes and tonsils.
• Concentration: 0.1 mg/mL
• Buffer: PBS, 0.1% BSA, 0.05% azide
• Molecular Weight: ~110 kDa
• Additionnal Information: Immunohistology Frozen Only 0.5-1.0 ug/mL|Immunofluorescence 0.5-1 ug/mL|Flow Cytometry 0.5-1 ug/million cells/0.1 mL|Does not react with pig or sheep, others not tested|Optimal dilution for a specific application should be determined by user
• References & Citations: Note: References for this clone sold by other suppliers may be listed for expected applications. Cancer Res (2005) 65(15): 6950-6. (functional studies) J Biol Chem (2001) 276(22): 19532-19539. (Flow) BMC Cancer (2011) 11:51. (IF)
• Shipping Conditions: Room temperature
• Storage Conditions: 4°C; Stable at room temperature or 37°C (98°F) for 7 days.
• Shelf Life: 2 years