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DS06652923

CAT: 0804-HY-162881Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162881Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DS06652923 is an orally active EGFR triple mutation inhibitor. DS06652923 has a growth inhibition effect on Ba/F3 EGFR del19/T90M/C797S cells, with a GI50 value of 9.4 nM. DS06652923 can lead to tumor regression in Ba/F3 xenograft models[1].
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ds06652923.html
Smiles
CC(C)OC1=CC(NC2=CC=NC(C3=CN(S(=O)(C4CC4)=O)N=C3)=N2)=NC=C1C5=CN(C6CCN(C)CC6)N=C5OC(F)F
Molecular Formula
C28H33F2N9O4S
Molecular Weight
629.68
References & Citations
[1]Kageji H, et al. Discovery of a potent, selective, and orally available EGFR C797S mutant inhibitor (DS06652923) with in vivo antitumor activity. Bioorg Med Chem. 2024 Sep 1;111:117862.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T200714-01DS06652923

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