Peramivir

• Description:

  Peramivir is an novel cyclopentane neuraminidase inhibitor of influenza virus. Peramivir has antiviral activity and anti-cytokines stom effects. Peramivir can be used for the research of COVID-19[1][2][3].

• Product Name Alternative:

  RWJ-270201; BCX-1812

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  ERK; IKK; JNK; p38 MAPK; STAT

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling; MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/peramivir.html

• Purity:

  99.94

• Solubility:

  1 M HCl : 100 mg/mL|DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O[C@H]1[C@]([C@H](C(CC)CC)NC(C)=O)([H])[C@H](NC(N)=N)C[C@@H]1C(O)=O

• Molecular Formula:

  C15H28N4O4

• Molecular Weight:

  328.41

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Zhang C, et al. Peramivir, an anti-influenza virus drug, exhibits potential anti-cytokine storm effects [J]. Frontiers in Immunology, 2022, 13: 856327.|[2]Pascua P N Q, et al. Pathogenicity and peramivir efficacy in immunocompromised murine models of influenza B virus infection [J]. Scientific reports, 2017, 7 (1) : 7345.|[3]Alame M M, et al.. Peramivir: a novel intravenous neuraminidase inhibitor for treatment of acute influenza infections [J]. Frontiers in microbiology, 2016, 7: 450.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  ERK1; ERK2; IKK-α; STAT3

• Citation 01:

  Chemosphere. 2017 Feb:169:550-557.|Emerg Microbes Infect. 2025 Dec;14 (1) :2564308.|Int Immunopharmacol. 2023 Feb:115:109706.|Int J Infect Dis. 2024 Jun 27:107134.|Nat Commun. 2013;4:2854.|NPJ Digit Med. 2025 Nov 21, 8 (1) :712.|PLoS One. 2015 Jun 25;10 (6) :e0131412.|PLoS Pathog. 2024 Feb 14;20 (2) :e1011981.|Sci Rep. 2021 Aug 11;11 (1) :16293.|University of Glasgow. School of Cancer Sciences.|Antimicrob Agents Chemother. 2020 Jun 23;64 (7) :e00222-20.|bioRxiv. 2025 Nov 17:2025.11.17.688839.|PLoS One. 2018 Jul 12;13 (7) :e0200761.

• CAS Number:

  [330600-85-6]