VH 032 amide-PEG6-amine (hydrochloride)

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804-HY-163209

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CAS Number: 2763910-08-1
UNSPSC Description: VH 032 amide-PEG6-amine hydrochloride (Step 4) is a functionalized von-Hippel-Lindau protein-ligand (VHL) for PROTAC development, consisting of an E3 ligand and a PEG6 ligand. Terminal amines can be coupled to target protein ligands[1].
Target Antigen: E3 Ligase Ligand-Linker Conjugates
Type: Reference compound
Related Pathways: PROTAC
Applications: Cancer-programmed cell death
Field of Research: Cancer
Assay Protocol: https://www.medchemexpress.com/vh-032-amide-peg6-amine-hydrochloride.html
Solubility: 10 mM in DMSO
Smiles: NCCOCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O.Cl.Cl
Molecular Weight: 824.85
References & Citations: [1]Yimin Qian, et al. Compounds and methods for the targeted degradation of bromodomain-containing proteins. WO2017030814A1.2017-02-23.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

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