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BAY885

CAT: 0804-HY-112082-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112082-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAY885, a chemical probe, is a highly potent and selective ERK5 inhibitor with an IC50 of 35 nM. BAY885 shows weak inhibition on others kinases[1].
CAS Number
2307249-33-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ERK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BAY885.html
Purity
99.33
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(OC(F)(F)F)C=C1N)N(CC2)CCC2C3=NC=NC4=CC(N5CCN(C)CC5)=CN=C43
Molecular Formula
C25H28F3N7O2
Molecular Weight
515.53
Precautions
H302, H315, H319, H335
References & Citations
[1]Nguyen D, et al. Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl) pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5. J Med Chem. 2019 Jan 24;62 (2) :928-940.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK5

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