CD11b (C11b/660), 0.2mg/mL

CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an alpha chain and beta chain. Integrinα M combines with the Integrinβ2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3) . Integrinα M/β2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. The protein CD11b has been implicated in the various adhesion-related interactions of cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes. It is part of a heterodimer that consists of CD11b and CD18. It also modulates the uptake of complement-coated particles within the cell. It is commonly used as a microglial marker in tissues derived from the nervous system.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

9007-83-4

CD18; CD49d; Cell surface glycoprotein MAC-1 subunit alpha; Complement Component Receptor 3 Alpha; CR3 Alpha Chain (CR3A) ; Integrin alpha-M; Integrin beta 2 alpha subunit; Leukocyte adhesion receptor MO1; Ly-40; MAC1A; Macrophage antigen alpha polypeptide; MO1A; Neutrophil adherence receptor alpha M subunit

41116161

Primary and secondary antibodies for multiple methodology immunostaining detection application

ITGAM

3684

172631

P11215

P11215

CD11b|MAC-1

Recombinant human CD11b protein

CD11b | MAC-1

C11b/660

Primary

Animal

Animal

Immunology, Neuroscience

Human monocytes & granulocytes. Human lymph nodes and tonsils.

2 years

0.2 mg/mL

PBS, 0.05% BSA, 0.05% azide

95 kDa & 170 kDa

Springer T, et al. 1978. Eur. J. Immunol. 8:539. | Ault K and Springer T. 1981. J. Immunol. 126:359. | Springer TA, et al. 1982. Immunol. Rev. 68:171. | Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766. | Flotte TJ, et al. 1983. Am. J. Pathol. 111:112

RT (ND)

Stable at room temperature or 37°C (98°F) for 7 days.

Guaranteed for at least 24 months from date of receipt when stored as recommended

IgG2b, kappa

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)